Wang Liangxing_Faculty_The First Affiliated Hospital of Wenzhou Medical University
Home>Patient Care>Faculty>Wang Liangxing


Name



Wang Liangxing

  DepartmentRespiratory and Critical Care Medicinewang180.jpg
E-mail38805@163.com  DegreePh.D & MD
Title/Position

Vice President, Director, Wenzhou Medical University Director, Pulmonary Medical Center Director , the First Affiliated Hospital of Wenzhou Medical University

Professional SpecialtyPulmonary and critical care medicine
Education

Bachelor’s Degree : Wenzhou Medical University, Wenzhou, China ,

Major Field:         Medicine (Sept.1980-July.1985) 

Master’s Degree :   Wenzhou Medical University, Wenzhou, China ,

                     Major Field: Internal Medicine (Sept.1985-                              July.1988 )

Ph.D.& MD :          Huazhong University of Science and Technology,                          Wuhan, China,

Major Field:         Internal Medicine (Sept.2007- July.2011 )


Employment

Pulmonary Medical Center Director: (Dec.2007-Present) the First Affiliated Hospital of Wenzhou Medical University

Senior Physician: (Dec.2001-Present) the First Affiliated Hospital of Wenzhou Medical University 

Professor: (Dec.2000-Present) the First Affiliated Hospital of Wenzhou Medical University

Associate Senior Physician, Associate Professor: (Dec.1996- Dec.2000) the First Affiliated Hospital of Wenzhou Medical University 

Attending Physician: (Dec.1991- Dec.1996) the First Affiliated Hospital of Wenzhou Medical University

Residency: (Sep.1988-Dec.1991) the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.


Prizes and Awards

1. Study on the characteristics and molecular characteristics of clinical isolates of Staphylococcus aureus virulence and drug resistance, Chinese medical science and technology award, the first prize, 2011.

2. Study on the characteristics and molecular characteristics of clinical isolates of Staphylococcus aureus virulence and drug resistance, the government of Zhejiang Province, Zhejiang provincial science and technology award, the first prize, 2011.

3. Research series of Chronic hypoxia hypercapnia pulmonary hypertension mechanism and prevention of TCM and Western medicine combining, Zhejiang province science and technology award, the second prize, 2002

4.Comprehensive prevention and pathogenesis research of chronic pulmonary hypertension, Zhejiang provincial science and technology award, the second prize, 2016.

5. Comprehensive prevention and pathogenesis research of chronic pulmonary hypertension, science and technology progress award of Wenzhou, the first prize, 2016.

6. Study on the effects of injection of microparticles on pulmonary arterial pressure and lung tissue, Zhejiang provincial science and technology award, the third prize, 2008


Membership of Professional Societies/Committees

Deputy director of Committee of internal medicine of Zhejiang Medical Association

Deputy director of Committee of Zhejiang medical association respiratory disease branch

Deputy director of Committee of Zhejiang Medical Association and respiratory center of integrated traditional Chinese and Western Medicine

Editorial board member of Chinese Journal of Tuberculosis and Respiratory Diseases

Committee member of Chinese doctors association respiratory disease branch 

Editorial board member of Chinese Journal of Nosocomiology

Committee member of pulmonary embolism and pulmonary vascular disease group, Chinese medical association respiratory disease branch

Committee member of professional committee on sleep apnea, China sleep research association

Head of Zhejiang pulmonary vascular Association

Director of Committee of internal medicine of Wenzhou Medical Association

Director of Committee of Wenzhou medical association respiratory disease branch


Research Grants

National Key Research and Development Project (2016YFC1304104) Study on appropriate technology for early diagnosis of chronic lung disease.

National Natural Science Foundation of China (81470250) Study on the effects of endothelial-mesenchymal transformation and acycloside intervention on pulmonary arterial hypertension in A2AR knockout mice.

National Natural Science Foundation of China (81270110) Study on the effects of stromal cell-derived factor 1 and the receptor on pulmonary arterial hypertension in A2AR knockout mice.

National Natural Science Foundation of China (30871138) Study on the effects of resveratrol on pulmonary injury and pulmonary hypertension after pulmonary embolism.

National Natural Science Foundation of China (30670933) Study on the relationship of mitochondrial pathway mediated cell apoptosis with pulmonary angiogenesis in chronic hypoxic high - carbon pulmonary hypertension. 

National Natural Science Foundation of China (30472269) Study on the mechanism of curcumin inhibits chronic pulmonary arterial hypertension.

National Natural Science Foundation of China (30370612) Study on the relationship between osteopontin and pulmonary angiogenesis in chronic hypoxic high - carbon pulmonary hypertension.

Zhejiang Natural Science Foundation of China (Y2101208), The relationship of adenosine receptor and pulmonary angiogenesis in chronic hypoxic high - carbon pulmonary hypertension and the intervene effects of paeoniflorin.

Key projects of the ministry of education, Study on Puerarin inhibits chronic pulmonary hypertension and the expression of OPNmRNA.

Zhejiang science and technology department (C30011), Study on the mechanism of curcumin inhibits chronic pulmonary hypertension.

Zhejiang Natural Science Foundation of China (302762), Study on the relationship between thrombus/procyclic cycloelement system and chronic pulmonary hypertension microthrombosis.

Zhejiang Natural Science Foundation of China (301484), Study on the regulation effect of carbon monoxide system on high carbon dioxide high carbon dioxide pulmonary hypertension.

Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period, Study on the key technologies of the prevention and treatment of pulmonary embolism.

The National Key Technology R&D Program, Study on improving the diagnosis and treatment of pulmonary embolism.

Key project of Zhejiang provincial health department platform plan (012ZDA033), Study on the effects of stromal cell-derived factor 1 and the receptor on pulmonary arterial hypertension in A2AR knockout mice.


Publications

Selected Papers

Xiaoying Huanga*, Lizhen Zoua, Xiaoming Yua, Mayun Chena, Rui Guoa, Hui Caia, Dan Yaoa, Xiaomei Xua, Yanfan Chena, Cheng Dinga, Xueding Caia, and Liangxing Wang*,Salidroside attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2a receptor related mitochondria-dependent apoptosis pathway,Journal of Molecular and Cellular Cardiology,2015 May;82:153-66. 

Huang Xiaoying*, Fan Rong, Lu Yuanyuan, Yu Chang, Xu Xiaomei, Zhang Xie, Liu Panpan, Yan Shuangquan, Chen Chun, Wang Liangxing*. Regulatory effect of AMP-activated protein kinase on pulmonary hypertension induced by chronic hypoxia in rats: in vivo and in vitro studies. Molecular Biology Reports(Mol Biol Rep) 2014 Jun;41(6):4031-41. 

Xiaoying Huang*, Peiliang Wu, Mayun Chen, Zhimin Cui, Wei Mao, Kate Huang, Guoping Li, Manhuan Xu, Dan Yao, Liangxing Wang*, Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor induced SDF-1/CXCR4/PI3K/AKT signaling, Biomedical Science, 2017,24:52

Xiaoying Huang*, Yicheng He, Yanfan Chen, Caijun Dai, Dan Yao and Liangxing Wang*. Baicalin attenuates bleomycin-induced pulmonary fibrosis via adenosine A2a receptor related TGF-β1 induced ERK1/2 Signaling Pathway. BMC Pulmonary Medicine, (2016) ,16:132 

Wang Y, Ying L, Chen YY, Shen YL, Guo R, Jin KK, Wang LX, Induction of heme oxygenase-1 ameliorates vascular dysfunction in streptozotocin-induced type 2 diabetic rats, Vascul Pharmacol. 2014 Apr;61(1):16-24

Cai XH, Li XC, Jin SW, Liang DS, Wen ZW, Cao HC, Mei HF, Wu Y, Lin ZD, Wang LX, Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats, Exp Neurol. 2014 Jul;257:148-56

Yu F, Lu C, Liu Y, Sun H, Shang Y, Ding Y, Li D, Qin Z, Parsons C, Huang X, Li Y, Hu L, Wang L, Emergence of quinupristin/dalfopristin resistance among livestock-associated Staphylococcus aureus ST9 clinical isolates, Int J Antimicrob Agents. 2014 Nov;44(5):416-9

Yu F, Chen Q, Yu X, Pan J, Li Q, Yang L, Chen C, Zhuo C, Li X, Zhang X, Huang J, Wang L, High prevalence of  plasmid-mediated quinolone resistance determinant aac(6′)-Ib-cr amongst Salmonella enterica serotype Typhimurium isolates from hospitalised paediatric patients with diarrhoea in China, Int J Antimicrob Agents. 2011 Feb;37(2):152-5.

Yu F, Liu Y, Xu Y, Shang Y, Lou D, Qin Z, Parsons C, Zhou W, Huang X, Li Y, Hu L, Wang L, Expression of Panton-Valentine Leukocidin mRNA among Staphylococcus aureus Isolates Associates with Specific Clinical Presentations, PLoS One. 2013 Dec 12;8(12)

Xia X, Dai C, Zhu X, Liao Q, Luo X, Fu Y, Wang L, Identification of a Novel NLRP12 Nonsense Mutation (Trp408X) in the Extremely Rare Disease FCAS by Exome Sequencing, PLoS One. 2016 Jun 17;11(6)

Wang X, Lou M, Li Y, Ye W, Zhang Z, Jia X, Shi H, Zhu X, Wang L, Cardiovascular involvement in connective tissue disease: the role of interstitial lung disease, PLoS One. 2015 Mar 16;10(3)

Yu F, Yang L, Pan J, Chen C, Du J, Li Q, Huang J, Zhang X, Wang L, Prevalence of virulence genes among invasive and colonising Staphylococcus aureus isolates, J Hosp Infect. 2011 Jan;77(1):89-91

Yu F, Liu Y, Lu C, Lv J, Qi X, Ding Y, Li D, Huang X, Hu L, Wang L,Dissemination of fusidic acid resistance among Staphylococcus aureus clinical isolates, BMC Microbiol. 2015 Oct 13;15:210

Chun C, Yang W, Xueding C, Qi Z, Xiaoying H, Honglei X, Fangyou Y, Chan C, Yuanyuan L, Weixi Z, Dan Y, Zhoucang Z, Lehe Y, Cheng D, Liangxing W, Resveratrol downregulates acute pulmonary thromboembolism-induced pulmonary artery hypertension via p38 mitogen-activated protein kinase and monocyte chemoattractant protein-1 signaling in rats, Life Sci. 2012 May 22;90(19-20):721-7

Xie CL, Li JH, Wang WW, Zheng GQ, Wang LX ,Neuroprotective effect of ginsenoside-Rg1 on cerebral ischemia/reperfusion injury in rats by downregulating protease-activated receptor-1 expression, Life Sci. 2015 Jan 15;121:145-51

Wang XB, Wang W, Zhu XC, Ye WJ, Cai H, Wu PL, Huang XY, Wang LX, The potential of asiaticoside for TGF-beta1/Smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension, Life Sci. 2015 Sep 15;137:56-64

Yu F1, Li T, Huang X, Xie J, Xu Y, Tu J, Qin Z, Parsons C, Wang J, Hu L, Wang L,Virulence gene profiling and molecular characterization of hospital-acquired Staphylococcus aureus isolates associated with bloodstream infection, Diagn Microbiol Infect Dis. 2012 Dec;74(4):363-8

Yao D, Yu FY, Qin ZQ, Chen C, He SS, Chen ZQ, Zhang XQ, Wang LX, Molecular characterization of Staphylococcus aureus isolates causing skin and soft tissue infections (SSTIs), BMC Infect Dis. 2010 May 26;10:133

Yu FY, Yao D, Pan JY, Chen C, Qin ZQ, Parsons C, Yang LH, Li QQ, Zhang XQ, Qu D, Wang LX, High prevalence of plasmid-mediated 16S rRNA methylase gene rmtB among Escherichia coli clinical isolates from a Chinese teaching hospital, BMC Infect Dis. 2010 May 26;10:133

Cai XH, Xie YP, Li XC, Qu WL, Li T, Wang HX, Lv JQ, Wang LX, The prevalence and associated risk factors of sleep disorder-related symptoms in  pregnant women in China, Sleep Breath. 2013 Sep;17(3):951-6

Huang X, Xu X, Yu C, Fan R, Lu Y, Lu S, Wang L,Pulmonary sequestration with tuberculosis confined to the sequestrated lung, Ann Thorac Cardiovasc Surg. 2012;18(1):51-5

Yu F, Ying Q, Chen C, Li T, Ding B, Liu Y, Lu Y, Qin Z, Parsons C, Salgado C, Qu D, Pan J, Wang L, Outbreak of pulmonary infection caused by Klebsiella pneumoniae isolates harbouring blaIMP-4 and blaDHA-1 in a neonatal intensive care unit in China, J Med Microbiol. 2012 Jul;61(Pt 7):984-9

Huang X, Tang J, Cai H, Pan Y, He Y, Dai C, Chen A, Yu X, Chen M, Zou L, Wang L,Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway, Evid Based Complement Alternat Med. 2015;2015:272474

Yu F, Liu Y, Lv J, Qi X, Lu C, Ding Y, Li D, Liu H, Wang L,Antimicrobial susceptibility, virulence determinant carriage and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections, Braz J Infect Dis. 2015 Nov-Dec;19(6):614-22

Mayun Chen, Hui Cai, Peiliang Wu, Chang Yu, Dan Yao, Xiaomei Xu, Rong Fan, Cunlai Xu, Yanfan Chen, Liangxing Wang*, Xiaoying Huang*. Salidroside exerts protective effects against chronic hypoxia-induced pulmonary arterial hypertension via AMPKα1-dependent pathways. Am J Transl Res 2016;8(1):12-27 

Mayun Chen, Xiaomi Wang, Xianjuan Yu, Caijun Dai, Dunshun Chen, Chang Yu, Xiaomei Xu, Dan Yao, Li Yang, Yuping Li, Liangxing Wang*and Xiaoying Huang*. Pleural effusion as the initial clinical presentation in disseminated cryptococcosis and fungaemia: an unusual manifestation and a literature review, BMC Infectious Diseases, (2015) 15:385. 

Jingnan Lv, Xiuqin Qi,Dan Zhang, Zhou Zheng, Yuehui Chen, Yinjuan Guo, Shanshan Wang, Liang Chen, Barry N. Kreiswirth, Yi-Wei Tang, Zengqiang Chen, Longhua Hu, Liangxing Wang,* and Fangyou Yu,*First Report of Complete Sequence of a blaNDM-13-Harboring Plasmid from an Escherichia coli ST5138Clinical Isolate, Front Cell Infect Microbiol. 2016 Oct 13;6:130

Zhan L, Wang S, Guo Y, Jin Y, Duan J, Hao Z, Lv J, Qi X, Hu L, Chen L, Kreiswirth BN3, Zhang R, Pan J, Wang L, Yu F, Outbreak by Hypermucoviscous Klebsiella pneumoniae ST11 Isolates with Carbapenem Resistance in a Tertiary Hospital in China Front Cell Infect Microbiol. 2017 May 16;7:182

Yinjuan Guo,† Shanshan Wang,† Lingling Zhan, Ye Jin, Jingjing Duan, Zhihao Hao, Jingnan Lv, Xiuqin Qi,Liang Chen, Barry N. Kreiswirth, Liangxing Wang,* and Fangyou Yu,Microbiological and Clinical Characteristics of Hypermucoviscous Klebsiella pneumoniae Isolates Associated with Invasive Infections in China, Front Cell Infect Microbiol. 2017 Feb 1;7:24

Yu F, Wang S, Lv J, Qi X, Guo Y, Tang YW, Kreiswirth BN, Wang L, Chen L, Coexistence of OXA-48-producing Klebsiella pneumoniae and Escherichia coli in a hospitalized patient returned from Europe to China, Antimicrob Agents Chemother. 2017 Mar 24;61(4).

Li D, Guo Y, Wang S, Lv J, Qi X, Chen Z, Han L, Zhang X, Wang L, Yu F, capB2 Expression Is Associated with Staphylococcus aureus Pathogenicity, Front Microbiol. 2017 Feb 10;8:184

Lu C, Guo Y, Wang S, Wang Z, Chen L, Lv J, Qi X, Chen Z, Han L, Zhang X, Wang L, Yu F,Decreased Vancomycin MICs among Methicillin-Resistant Staphylococcus aureus Clinical Isolates at a Chinese Tertiary Hospital over a 12-year Period,  Front Microbiol. 2016 Oct 27;7:1714

Hu L, Liu Y, Deng L, Zhong Q, Hang Y, Wang Z, Zhan L, Wang L, Yu F, Outbreak by VentilatorAssociated ST11 K. pneumoniae with Coproduction of CTX-M-24 andKPC-2 in a SICU of a Tertiary Teaching Hospital in CentralChina, Front Microbiol. 2016 Aug 2;7:1190

Qian G, Cao J, Chen C, Wang L, Huang X, Ding C, Cai X, Yin F, Chu J, Li G, Ye J, Paeoniflorin Inhibits Pulmonary Artery Smooth Muscle Cells Proliferation via Upregulating A2B Adenosine Receptor in Rat, PLoS One. 2013 Jul 30;8(7)

Yu F, Chen Q, Yu X, Li Q, Ding B, Yang L, Chen C, Qin Z, Parsons C, Zhang X, Huang J, Luo Y, Wang L, Pan J, High prevalence of extended-spectrum beta lactamases among Salmonella enterica Typhimurium isolates from pediatric patients with diarrhea in China, PLoS One. 2011 Mar 1;6(3)

Du J, Chen C, Ding B, Tu J, Qin Z, Parsons C, Salgado C, Cai Q, Song Y, Bao Q, Zhang L, Pan J, Wang L, Yu F, Molecular characterization and antimicrobial susceptibility of nasal Staphylococcus aureus isolates from a Chinese medical college campus,  PLoS One. 2011;6(11)

Zhang X, Lou D, Xu Y, Shang Y, Li D, Huang X, Li Y, Hu L, Wang L, Yu F, First identification of coexistence of blaNDM-1 and blaCMY-42 among Escherichia coli ST167 clinical isolates, BMC Microbiol. 2013 Dec 5;13:282

Du J, Chen C, Ding B, Tu J, Qin Z, Parsons C, Salgado C, Cai Q, Song Y, Bao Q, Zhang L, Pan J, Wang L, Yu F, Multiple system morbidities associated with children with snore symptom Pediatr Pulmonol, PLoS One. 2011;6(11)

Li T, Yu X, Xie J, Xu Y, Shang Y, Liu Y, Huang X, Qin Z, Parsons C, Hu L, Salgado C, Wang L, Yu F, Carriage of virulence factors and molecular characteristics of Staphylococcus aureus isolates associated with bloodstream, and skin and soft tissue infections  in children. Epidemiol Infect. 2013 Oct;141(10):2158-62

Hu L, Zhong Q, Shang Y, Wang H, Ning C, Li Y, Hang Y, Xiong J, Wang X, Xu Y, Qin Z, Parsons C, Wang L, Yu F, The prevalence of carbapenemase genes and plasmid-mediated quinolone resistance determinants in carbapenem-resistant Enterobacteriaceae from five teaching hospitals in central China, Epidemiol Infect. 2014 Sep;142(9)

Liu H, Lv J, Qi X, Ding Y, Li D, Hu L, Wang L, Yu F, The carriage of the serine-aspartate repeat protein-encoding sdr genes among Staphylococcus aureus lineages, Braz J Infect Dis. 2015 Sep-Oct;19(5):498-502

Wang LX, Sun Y, Chen C, Huang XY, Lin Q, Qian GQ, Dong W, Chen YF, Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats Pulmonary sequestration with tuberculosis confined to the sequestrated lung, Chin Med J (Engl). 2009 Jun 20;122(12):1380-7

Huang X, Xu X, Yu C, Fan R, Lu Y, Lu S, Wang L, Pulmonary sequestration with tuberculosis confined to the sequestrated lung, Ann Thorac Cardiovasc Surg. 2012;18(1):51-5.

Wang XB, Zhu XC, Huang XY, Ye WJ, Wang LX, Fanconi syndrome due to prolonged use of low-dose adefovir, J Res Med Sci. 2015 Apr;20(4):416-9.


Prev:none

Next:Wu Jiansheng